George is alone in the house with his Grandma – the most horrible Grandma that ever was. She is grouchy and grizzled and grumpy.
Luckily, George knows how to cure her of her bad attitude. He decides to brew up an extra-special remedy – a Grandma Medicine. He mixes together all sorts of things and creates the most marvelous medicine for his grouchy grandma.
The problem is, George doesn’t know exactly what his medicine will do. From growing into a gigantic ball of air, to growing so tall that she bursts through the ceiling, George’s medicine has a number of amazing and hilarious results. In the meantime, George struggles to get the magical effects of his medicine under control.